Methyl iodide → HCID 20437408、化合物

HRID 1980090ノート

反応式

HRID 1980090 の反応式
[OH:1][CH:2]([CH2:9][NH:10][S:11]([C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16][CH:15]=1)(=[O:13])=[O:12])[CH2:3][N:4]1[CH2:8][CH2:7][CH2:6][CH2:5]1.[CH3:24][I:25]>CO>[I-:25].[OH:1][CH:2]([CH2:9][NH:10][S:11]([C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16][CH:15]=1)(=[O:13])=[O:12])[CH2:3][N+:4]1([CH3:24])[CH2:8][CH2:7][CH2:6][CH2:5]1

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 20437405HCID 20437405、化合物

生成物 1

HCID 20437408HCID 20437408、化合物収率 545.8%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 1-[2-hydroxy-3-(1-naphthalenesulphonamido)propyl]pyrrolidine (2 g; 0.0005 mol) in methanol (50 ml) was added methyl iodide (6.9 g; 0.05 mol). The mixture was left at room temperature 12 hours. The reaction mixture was evaporated to dryness and the residue was recrystallized from ethanol (20 ml) to obtain the product (1.3 g).

後処理

  1. customThe reaction mixture was evaporated to dryness
  2. customthe residue was recrystallized from ethanol (20 ml)

出典と根拠

ORDレコード
ord-dfe7be1f650f49aaa7511649034dfcf6
出典データセット
uspto-grants-1984_11
特許番号
US04485108

反応ノート

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