Chloroform → 3-[4-(Hexadecylamino)benzoyl]-4-carboethoxythiazolidine

HRID 1980171

反応式

HRID 1980171 の反応式
Cl.[CH2:2]([NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].[S:28]1[CH2:32][CH:31]([C:33]([O:35][CH2:36][CH3:37])=[O:34])[NH:30][CH2:29]1.C(Cl)(Cl)Cl.C(N(CC)CC)C>C(Cl)Cl>[CH2:2]([NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([N:30]2[CH:31]([C:33]([O:35][CH2:36][CH3:37])=[O:34])[CH2:32][S:28][CH2:29]2)=[O:24])=[CH:21][CH:20]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]

参加物

6

反応物 4

HCID 6212ChloroformHCID 8471TriethylamineHCID 103574Ethyl thiazolidine-4-carboxylateHCID 132553224-Hexadecylaminobenzoyl chloride hydrochloride

生成物 1

HCID 204373423-[4-(Hexadecylamino)benzoyl]-4-carboethoxythiazolidine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

One-tenth mole of 4-(hexadecylamino)benzoyl chloride hydrochloride in methylene chloride is added to a solution of 0.1 mole of ethyl thiazolidine-4-carboxylate in chloroform containing two equivalents of triethylamine. After 5 hours at 20° C. the solution is filtered and evaporated to a white solid which is recrystallized from acetonitrile.

後処理

  1. filtrationAfter 5 hours at 20° C. the solution is filtered
  2. customevaporated to a white solid which
  3. customis recrystallized from acetonitrile

出典と根拠

ORDレコード
ord-47fe206ddad44a95b5cb045531ee3cf0
出典データセット
uspto-grants-1984_11
特許番号
US04485105

関連ノート

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