Dicyclohexylcarbodiimide → N-[N-trifluoroacetyl-4-(hexadecylamino)benzoyloxy]succinimide

HRID 1980193ノート

反応式

HRID 1980193 の反応式
[F:1][C:2]([F:32])([F:31])[C:3]([N:5]([C:22]1[CH:30]=[CH:29][C:25]([C:26]([OH:28])=[O:27])=[CH:24][CH:23]=1)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])=[O:4].O1CCOCC1.O[N:40]1[C:44](=[O:45])[CH2:43][CH2:42][C:41]1=[O:46].C1(N=C=NC2CCCCC2)CCCCC1>O.CCCCCC>[F:1][C:2]([F:31])([F:32])[C:3]([N:5]([C:22]1[CH:30]=[CH:29][C:25]([C:26]([O:28][N:40]2[C:44](=[O:45])[CH2:43][CH2:42][C:41]2=[O:46])=[O:27])=[CH:24][CH:23]=1)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])=[O:4]

参加物

7

反応物 4

HCID 10868DicyclohexylcarbodiimideHCID 312751,4-DioxaneHCID 80170N-HydroxysuccinimideHCID 20437350N-trifluoroacetyl-4-(hexadecylamino)benzoic acid

生成物 1

HCID 20437360N-[N-trifluoroacetyl-4-(hexadecylamino)benzoyloxy]succinimide

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8058Hexane溶媒

実験手順

To a stirred ice-cold solution of 18.3 g. of p-(2,2,2-trifluoro-N-hexadecylacetamido)benzoic acid in 80 ml. of dioxane is added successively 4.84 g. of N-hydroxysuccinimide and 9.16 g. of dicylohexylcarbodiimide. After 18 hours at 0°-5° C. the mixture is stirred vigorously for one hour with hexane and water and filtered. The hexane layer is washed with water, dried over magnesium sulfate, and concentrated to give an oil.

後処理

  1. filtrationfiltered
  2. washThe hexane layer is washed with water
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated
  5. customto give an oil

出典と根拠

ORDレコード
ord-123a317fa24c47769f939d8663431f36
出典データセット
uspto-grants-1984_11
特許番号
US04485105

反応ノート

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