2,6-Difluorobenzoyl isocyanate → HCID 13242655、化合物

HRID 1980326ノート

反応式

HRID 1980326 の反応式
[Cl:1][C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=1.[F:16][C:17]1[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[C:18]=1[C:19]([N:21]=[C:22]=[O:23])=[O:20]>C(#N)C>[F:16][C:17]1[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[C:18]=1[C:19]([NH:21][C:22]([NH:8][C:6]1[CH:5]=[CH:4][C:3]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)=[C:2]([Cl:1])[N:7]=1)=[O:23])=[O:20]

参加物

4

反応物 2

HCID 27333692,6-Difluorobenzoyl isocyanateHCID 135028596-Chloro-5-(4-chlorophenyl)pyridin-2-amine

生成物 1

HCID 13242655HCID 13242655、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

6-Chloro-5-(4-chlorophenyl)-2-pyridylamine (0.3 gram) was dissolved in 25 ml acetonitrile and treated with 2,6-difluorobenzoyl isocyanate (0.5 gram) under nitrogen at room temperature. A precipitate formed almost immediately and after about three hours stirring, the solid was collected and washed with acetonitrile, yield 0.36 gram, m.p. 237°-241° C.

後処理

  1. customA precipitate formed almost immediately and after about three hours
  2. customthe solid was collected
  3. washwashed with acetonitrile, yield 0.36 gram, m.p. 237°-241° C.

出典と根拠

ORDレコード
ord-1ea592183ec74c84867450e0974088fc
出典データセット
uspto-grants-1985_04
特許番号
US04508722

反応ノート

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