Ethanol → 6-(4-Chlorophenyl)pyridine-3-carboxamide
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[CH:12][C:11]([C:14]#[N:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.OO.[OH-].[Na+].C([OH:22])C>CC(C)=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[CH:12][C:11]([C:14]([NH2:15])=[O:22])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1参加物
6
実験手順
6-(4-Chlorophenyl)-3-pyridinecarbonitrile (1.61 grams), 30% hydrogen peroxide (3.0 cc.), 6N sodium hydroxide (0.3 cc.), and about 6 ml ethanol were placed in a reaction vessel and cooled slightly. The reaction temperature rose to about 50° C. and the mixture was stirred for about 1 hour. After the reaction had cooled, a solid precipitate formed and was collected by filtration. As indicated by TLC, pure product was obtained by heating the solid in refluxing acetone, yield 0.4 gram, m.p. 245°-258° C.
後処理
- temperaturecooled slightly
- customrose to about 50° C.
- temperatureAfter the reaction had cooled
- customa solid precipitate formed
- filtrationwas collected by filtration
- custompure product was obtained
- temperatureby heating the solid
出典と根拠
- ORDレコード
- ord-d8c1de284f5d40ea924dc294833c180c
- 出典データセット
- uspto-grants-1985_04
- 特許番号
- US04508722
反応ノート
読み込み中…