Benzene, 2-chloro-1-(3,4-dinitrophenoxy)-4-(trifluoromethyl)- → methyl P-ethyl-2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenylphosphinate

HRID 1980447ノート

反応式

HRID 1980447 の反応式
[Cl:1][C:2]1[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[CH:17][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[C:7]([N+]([O-])=O)[CH:6]=1.[CH2:25]([P:27]([O:30]C)[O:28][CH3:29])[CH3:26]>C(#N)C>[CH2:25]([P:27]([C:7]1[CH:6]=[C:5]([O:4][C:3]2[CH:17]=[CH:18][C:19]([C:21]([F:24])([F:23])[F:22])=[CH:20][C:2]=2[Cl:1])[CH:10]=[CH:9][C:8]=1[N+:11]([O-:13])=[O:12])(=[O:30])[O:28][CH3:29])[CH3:26]

参加物

4

反応物 2

HCID 156238Benzene, 2-chloro-1-(3,4-dinitrophenoxy)-4-(trifluoromethyl)-HCID 2784207Dimethyl ethylphosphonite

生成物 1

HCID 13456449methyl P-ethyl-2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenylphosphinate

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of 4-(2-chloro-4-trifluoromethylphenoxy)-1,2-dinitrobenzene (1.6 g, 4.4 mmol), dimethyl ethylphosphonite (1 ml, 8.8 mmol) and acetonitrile (6 ml) is stirred at room temperature overnight. The reaction mixture is concentrated to dryness, and the residue is purified by preparative thin layer chromatography (silica gel, eluting with 10% ethyl acetate/hexane) to give methyl P-ethyl-2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenylphosphinate.

後処理

  1. concentrationThe reaction mixture is concentrated to dryness
  2. customthe residue is purified by preparative thin layer chromatography (silica gel, eluting with 10% ethyl acetate/hexane)

出典と根拠

ORDレコード
ord-1e0abddf00e54693a35b1fcc5cf6e3bc
出典データセット
uspto-grants-1985_04
特許番号
US04509970

反応ノート

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