Tetrahydrofuran → HCID 178467223、化合物

HRID 1980586ノート

反応式

HRID 1980586 の反応式
[CH3:1][C:2]1[N:3](C(=O)C)[CH:4]=[CH:5][N:6]=1.[O:10]1CC[CH2:12][CH2:11]1>>[CH3:1][C:2]1[NH:6][CH:5]=[C:4]([C:11](=[O:10])[CH3:12])[N:3]=1

参加物

3

反応物 2

HCID 8028TetrahydrofuranHCID 130588401-(2-Methyl-1-imidazolyl)ethanone

生成物 1

HCID 178467223HCID 178467223、化合物収率 45%

実験手順

5.75 g (46.3 mmol) of 1-(2-methyl-1-imidazolyl)ethanone was dissolved in 600 ml tetrahydrofuran and photolyzed in a quartz flask with a short wave u.v. light source (2537 nm) for 18 hours. The tetrahydrofuran solution was concentrated in vacuo to an oil and chromatographed on silica gel using 5% methanol in chloroform as eluent to give 2.6 g (45%) 1-(2-methyl-4-imidazolyl)ethanone, mp 123°-5°.

後処理

  1. customphotolyzed in a quartz flask with a short wave u.v
  2. concentrationThe tetrahydrofuran solution was concentrated in vacuo to an oil
  3. customchromatographed on silica gel using 5% methanol in chloroform as eluent

出典と根拠

ORDレコード
ord-d52c0e1cedd742de95eb5bc300b9d76f
出典データセット
uspto-grants-1985_04
特許番号
US04510313

反応ノート

読み込み中…