3,7-Dichloroquinoline-8-carbonitrile → 7-(Butylamino)-3-chloroquinoline-8-carbonitrile
反応式
[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7](Cl)[C:6]=2[C:13]#[N:14]>C(N)CCC>[CH2:3]([NH:4][C:7]1[C:6]([C:13]#[N:14])=[C:5]2[C:10]([CH:11]=[C:2]([Cl:1])[CH:3]=[N:4]2)=[CH:9][CH:8]=1)[CH2:2][CH2:11][CH3:10]参加物
3
実験手順
44.5 g of 3,7-dichloro-8-cyanoquinoline in 200 g of n-butylamine were heated at 80° C. for 14 hours, the solution was poured onto ice water and extracted with twice 100 ml of methylene chloride, the combined extracts were dried with Na2SO4 and evaporated down, the oily residue was treated with ether, and the precipitated solid was filtered off under suction. 39 g of 7-n-butylamino-3-chloro-8-cyanoquinoline of melting point 89° C. were obtained. Yield: 75% of theory.
後処理
- additionthe solution was poured onto ice water
- extractionextracted with twice 100 ml of methylene chloride
- dry with materialthe combined extracts were dried with Na2SO4
- customevaporated down
- additionthe oily residue was treated with ether
- filtrationthe precipitated solid was filtered off under suction
出典と根拠
- ORDレコード
- ord-dc737421c13d49a0b0b64fab089ffe41
- 出典データセット
- uspto-grants-1985_04
- 特許番号
- US04511393
反応ノート
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