Hydroxyamine hydrochloride → 3,7-Dichloroquinoline-8-carbonitrile

HRID 1980754ノート

反応式

HRID 1980754 の反応式
[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([Cl:12])[C:6]=2[CH:13](Cl)Cl.Cl.[NH2:17]O.C([O-])=O.[Na+]>C(O)=O.O>[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([Cl:12])[C:6]=2[C:13]#[N:17]

参加物

6

反応物 3

HCID 443297Hydroxyamine hydrochlorideHCID 2723810Sodium FormateHCID 130907853,7-Dichloro-8-(dichloromethyl)quinoline

生成物 1

HCID 130907923,7-Dichloroquinoline-8-carbonitrile収率 78.5%

試薬・触媒・溶媒 2

HCID 284Formic Acid溶媒HCID 962Water溶媒

実験手順

28.1 parts by weight of the 3,7-dichloro-8-dichloromethylquinoline thus obtained, 6.95 parts by weight of hydroxylamine hydrochloride and 13.6 parts by weight of sodium formate in 200 ml of formic acid and 60 ml of water were stirred for 12 hours at 100° C., the reaction solution was poured onto ice, the precipitated solid was filtered off under suction, washed neutral with water and dried. 19 parts by weight of 3,7-dichloro-8-cyanoquinoline of melting point 222° C. were obtained. Yield: 78.5% of theory.

後処理

  1. additionthe reaction solution was poured onto ice
  2. filtrationthe precipitated solid was filtered off under suction
  3. washwashed neutral with water
  4. customdried

出典と根拠

ORDレコード
ord-3ee7a7a981954f159dd551750df7ed5e
出典データセット
uspto-grants-1985_04
特許番号
US04511393

反応ノート

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