Sodium Hydroxide → 5-Benzoyl-1-methyl-1h-pyrrole-2-carboxylic acid

HRID 1980953ノート

反応式

HRID 1980953 の反応式
[CH3:1][N:2]1[C:6]([C:7](=[O:14])[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:5][CH:4]=[C:3]1[C:15]([O:17]C)=[O:16].[OH-].[Na+]>CO>[CH3:1][N:2]1[C:6]([C:7](=[O:14])[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:5][CH:4]=[C:3]1[C:15]([OH:17])=[O:16]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 12897104Methyl 1-Methyl-5-benzoylpyrrole-2-carboxylate

生成物 1

HCID 128971035-Benzoyl-1-methyl-1h-pyrrole-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methyl 1-methyl-5-benzoylpyrrole-2-carboxylate (0.78 g.) was heated on a steam bath for 1 hour with 40 ml. of 1N sodium hydroxide and 20 ml. of methanol. The reaction mixture was cooled to room temperature, extracted with ether, made acid with conc. hydrochloric acid and 1-methyl-5-benzoylpyrrole-2-carboxylic acid recovered by filtration (0.47 g., m.p. 178°-181° C.). Recrystallization from acetone/hexane afforded product for analysis (0.34 g., m.p. 178°-180° C.).

後処理

  1. extractionextracted with ether
  2. filtrationrecovered by filtration (0.47 g., m.p. 178°-181° C.)
  3. customRecrystallization from acetone/hexane afforded product for analysis (0.34 g., m.p. 178°-180° C.)

出典と根拠

ORDレコード
ord-876abd5935df4884a53cd882014b72cd
出典データセット
uspto-grants-1985_04
特許番号
US04511575

反応ノート

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