Hydrochloric Acid → 5-(4-Chlorophenylthio)pyrrole-3-carboxylic Acid
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[NH:13][CH:12]=[C:11]([C:14]([O:16]C)=[O:15])[CH:10]=2)=[CH:4][CH:3]=1.[OH-].[Na+].Cl>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:8][C:9]2[NH:13][CH:12]=[C:11]([C:14]([OH:16])=[O:15])[CH:10]=2)=[CH:6][CH:7]=1参加物
5
実験手順
Methyl 5-(4-chlorophenylthio)pyrrole-3-carboxylate (1.4 g.) was combined with 20 ml. of methanol and 20 ml. of 1N sodium hydroxide and heated on a steam bath for 2 hours. The reaction was cooled, acidified with conc. hydrochloric acid. and the crude product which precipitated, collected by filtration. Two recrystallizations from acetone/hexane afforded purified 5-(4-chlorophenylthio)pyrrole-3-carboxylic acid (740 mg., m.p. 171°-173° C.).
後処理
- temperatureThe reaction was cooled
- customand the crude product which precipitated
- filtrationcollected by filtration
- customTwo recrystallizations from acetone/hexane
- customafforded
- custompurified 5-(4-chlorophenylthio)pyrrole-3-carboxylic acid (740 mg., m.p. 171°-173° C.)
出典と根拠
- ORDレコード
- ord-82ecab0a366a4ff4976e2e9f6b503c12
- 出典データセット
- uspto-grants-1985_04
- 特許番号
- US04511576
反応ノート
読み込み中…