Sodium Hydroxide → HCID 12897098、化合物

HRID 1981030ノート

反応式

HRID 1981030 の反応式
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][C:7]2[CH:8]=[C:9]([C:12]([O:14]CCO)=[O:13])[NH:10][CH:11]=2)=[CH:4][CH:3]=1.[OH-].[Na+]>CC(C)=O>[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][C:7]2[CH:8]=[C:9]([C:12]([OH:14])=[O:13])[NH:10][CH:11]=2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 20400896HCID 20400896、化合物

生成物 1

HCID 12897098HCID 12897098、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

2-Hydroxyethyl 4-(4-chlorophenoxy)pyrrole-2-carboxylate (400 mg.) was dissolved in 10 ml. of acetone and 10 ml. of 1N sodium hydroxide and left to stand at room temperature for approximately 16 hours. Acetone was evaporated in vacuo, the aqueous residue was acidified with conc. hydrochloric acid and crystalline product (320 mg.) recovered by filtration. Recrystallization from ether/hexane of 400 mg. of product prepared in this manner afforded purified 4-(4-chlorophenoxy)pyrrole-2-carboxylic acid (234 mg., m.p. 188°-190° C., m/e 237).

後処理

  1. customAcetone was evaporated in vacuo
  2. filtrationrecovered by filtration
  3. customRecrystallization from ether/hexane of 400 mg
  4. customof product prepared in this manner
  5. customafforded
  6. custompurified 4-(4-chlorophenoxy)pyrrole-2-carboxylic acid (234 mg., m.p. 188°-190° C., m/e 237)

出典と根拠

ORDレコード
ord-81d9af303243478fb5edb6e1aab68f61
出典データセット
uspto-grants-1985_04
特許番号
US04511576

反応ノート

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