Hydrogen Peroxide → 4-(2-Hydroxyethoxy)phenol

HRID 1981061ノート

反応式

HRID 1981061 の反応式
CC([C:4]1[CH:13]=[CH:12][C:7]([O:8][CH2:9][CH2:10][OH:11])=[CH:6][CH:5]=1)=C.OO.[OH:16]S(O)(=O)=O.[O-]S([O-])=O.[Na+].[Na+]>CO>[OH:11][CH2:10][CH2:9][O:8][C:7]1[CH:12]=[CH:13][C:4]([OH:16])=[CH:5][CH:6]=1

参加物

6

反応物 4

HCID 784Hydrogen PeroxideHCID 1118Sulfuric AcidHCID 24437Sodium SulfiteHCID 137506132-(4-(1-Methylethenyl)phenoxy)ethanol

生成物 1

HCID 98340144-(2-Hydroxyethoxy)phenol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

To a mixture of 2.50 g 2-(4-(1-methylethenyl)phenoxy)ethanol, 10 ml methanol, and 1.1 equivalents 50% aqueous H2O2 were added 0.1 equivalent 98% H2SO4. The reaction mixture warmed itself to reflux which subsided in a few minutes. After addition of 0.2 equivalent Na2SO3, methanol was removed under reduced pressure. The residue was taken up in ether, dried over Na2SO4 and NaHCO3, and filtered. Removal of solvent left 4-(2-hydroxyethoxy)phenol in quantitative yield.

後処理

  1. temperatureThe reaction mixture warmed itself
  2. temperatureto reflux which
  3. waitsubsided in a few minutes
  4. customwas removed under reduced pressure
  5. dry with materialdried over Na2SO4 and NaHCO3
  6. filtrationfiltered
  7. customRemoval of solvent
  8. waitleft 4-(2-hydroxyethoxy)phenol in quantitative yield

出典と根拠

ORDレコード
ord-370c9a8b03b54f87a46c2e069968cf21
出典データセット
uspto-grants-1985_04
特許番号
US04511731

反応ノート

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