Hydrochloric Acid → 3-ethyl-5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole hydrochloride

HRID 1981167

反応式

HRID 1981167 の反応式
[ClH:1].[CH2:2]([C:4]1[N:8]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:7]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[N:6][N:5]=1)[CH3:3].C(OC(C)C)(C)C>C(O)C>[ClH:1].[CH2:2]([C:4]1[N:8]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:7]([C:15]2[CH:16]=[CH:17][C:18]([O:21][CH3:22])=[CH:19][CH:20]=2)=[N:6][N:5]=1)[CH3:3]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 7914Diisopropyl EtherHCID 130540223-ethyl-5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole

生成物 1

HCID 201515513-ethyl-5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole hydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

2.85 ml of a 6.4N hydrogen chloride solution in ethanol were added to a solution of 5.1 g of the product of Example 6 in 5.1 ml of ethanol and then isopropyl ether was added thereto. The mixture was filtered and the recovered product was empasted several times with isopropyl ether, filtered and was dried. The product was dissolved in 350 ml of tetrahydrofuran and the solution was filtered and concentrated to a volume of 75 ml. The mixture was cooled, iced and filtered and the recovered product was washed with tetrahydrofuran and dried to obtain 3.3 g of 3-ethyl-5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole hydrochloride melting towards 150° C. with decomposition.

後処理

  1. filtrationThe mixture was filtered
  2. filtrationfiltered
  3. customwas dried
  4. dissolutionThe product was dissolved in 350 ml of tetrahydrofuran
  5. filtrationthe solution was filtered
  6. concentrationconcentrated to a volume of 75 ml
  7. temperatureThe mixture was cooled
  8. filtrationiced and filtered
  9. washthe recovered product was washed with tetrahydrofuran
  10. customdried

出典と根拠

ORDレコード
ord-f58a4cb903144eaea8183783cc77a855
出典データセット
uspto-grants-1985_04
特許番号
US04512997

関連ノート

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