Imidazole → Climbazole

HRID 1981290

反応式

HRID 1981290 の反応式
Br[CH:2]([O:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=1)[C:3](=[O:8])[C:4]([CH3:7])([CH3:6])[CH3:5].[NH:17]1[CH:21]=[CH:20][N:19]=[CH:18]1.N1C=CN=C1C(C(C(C1NC=CN=1)=O)=O)=O.O>C(#N)C>[CH3:5][C:4]([C:3]([CH:2]([O:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=1)[N:17]1[CH:18]=[N:19][CH:20]=[CH:21]1)=[O:8])([CH3:7])[CH3:6]

参加物

6

反応物 4

HCID 795ImidazoleHCID 962WaterHCID 132691431-Bromo-1-(4-chlorophenoxy)-3,3-dimethylbutan-2-oneHCID 21924262HCID 21924262、化合物

生成物 1

HCID 37907Climbazole

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

The antigingivitis agent utilized in present invention is 1-imidazoyl-(p-chlorophenoxy)3-3-dimethyl 2-butanone having the structural formula: ##STR2## which is prepared by reacting 1-bromo-1-(4-chlorophenoxy)-3,3-dimethyl-2-butanone with imidazole dissolved in acetonitrile as disclosed in U.S. Pat. Nos. 3,812,142 and 3,903,287, which is made a part of this specification. This imidazoyl ketone is a water insoluble crystalline powder having a melting point of 94.5°-97.8° C. which may be obtained from the Bayer Company as Climbazole. Due to the water insolubility of this imidazole compound, it must first be solubilized in a nonionic compound prior to the addition of ionic materials in an aqueous medium.

後処理

  1. custom##STR2## which is prepared

出典と根拠

ORDレコード
ord-0c06c30f47d243f7943f6a72356ccafd
出典データセット
uspto-grants-1985_04
特許番号
US04514382

関連ノート

読み込み中…