3-Trifluoromethyl-4'-benzyloxy-alpha-ethyl-benzhydrol → 3-Trifluoromethyl-4'-hydroxy-alpha-ethylbenzhydrol

HRID 1981558

反応式

HRID 1981558 の反応式
[F:1][C:2]([F:28])([F:27])[C:3]1[CH:4]=[C:5]([CH:24]=[CH:25][CH:26]=1)[C:6]([CH2:22][CH3:23])([OH:21])[C:7]1[CH:12]=[CH:11][C:10]([O:13]CC2C=CC=CC=2)=[CH:9][CH:8]=1.[H][H]>[Pd].CO>[F:1][C:2]([F:27])([F:28])[C:3]1[CH:4]=[C:5]([CH:24]=[CH:25][CH:26]=1)[C:6]([CH2:22][CH3:23])([OH:21])[C:7]1[CH:8]=[CH:9][C:10]([OH:13])=[CH:11][CH:12]=1

参加物

5

反応物 2

HCID 202398663-Trifluoromethyl-4'-benzyloxy-alpha-ethyl-benzhydrolHCID 178418361HCID 178418361、化合物

生成物 1

HCID 1818763-Trifluoromethyl-4'-hydroxy-alpha-ethylbenzhydrol

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

54.1 g. of 3-trifluoromethyl-4'-benzyloxy-α-ethyl-benzhydrol in 541 ml. of methanol are hydrogenated under atmospheric pressure, in the presence of 27.1 g. of a 10% palladium-on-charcoal catalyst. When the uptake of the calculated amount of hydrogen is complete, the catalyst is filtered off, and the solvent is distilled off under reduced pressure. The crude product is decoloured with charcoal in ethyl acetate, and recrystallized from a mixture of ethyl acetate and n-hexane. 30.8 g. of the named compound are obtained, melting at 102.5° to 103° C.

後処理

  1. filtrationthe catalyst is filtered off
  2. distillationthe solvent is distilled off under reduced pressure
  3. customrecrystallized from a mixture of ethyl acetate and n-hexane
  4. customof the named compound are obtained

出典と根拠

ORDレコード
ord-7fc03fb4c9b04d1a902be11de0f1e52a
出典データセット
uspto-grants-1986_06
特許番号
US04593047

関連ノート

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