Acetamide, 2-chloro-N-(chloromethyl)-N-(2-ethyl-6-methylphenyl)- → 2-chloro-2'-methyl-6'-ethyl-N-(4-chloro-3,5-dimethylpyrazol-1-yl-methyl)-acetanilide

HRID 1981603ノート

反応式

HRID 1981603 の反応式
[Cl:1][CH2:2][C:3]([N:5]([CH2:15]Cl)[C:6]1[C:11]([CH2:12][CH3:13])=[CH:10][CH:9]=[CH:8][C:7]=1[CH3:14])=[O:4].[Cl:17][C:18]1[C:19]([CH3:24])=[N:20][NH:21][C:22]=1[CH3:23]>COCCOC>[Cl:1][CH2:2][C:3]([N:5]([CH2:15][N:20]1[C:19]([CH3:24])=[C:18]([Cl:17])[C:22]([CH3:23])=[N:21]1)[C:6]1[C:11]([CH2:12][CH3:13])=[CH:10][CH:9]=[CH:8][C:7]=1[CH3:14])=[O:4]

参加物

4

反応物 2

HCID 180581Acetamide, 2-chloro-N-(chloromethyl)-N-(2-ethyl-6-methylphenyl)-HCID 6736884-chloro-3,5-dimethyl-1H-pyrazole

生成物 1

HCID 130699242-chloro-2'-methyl-6'-ethyl-N-(4-chloro-3,5-dimethylpyrazol-1-yl-methyl)-acetanilide

試薬・触媒・溶媒 1

HCID 80711,2-Dimethoxyethane溶媒

反応条件

温度
0 °C

実験手順

21.4 parts by weight of 2-chloro-2'-methyl-6'-ethyl-N-chloromethyl acetanilide and 20.2 parts by weight of 4-chloro-3,5-dimethylpyrazole are refluxed for 10 hours in 100 parts by volume of glycol dimethyl ether. After cooling the mixture to 0° C., it is filtered, and the filtrate, concentrated to 23.8 parts by weight, is filtered with 600 parts by volume of chloroform through 50 parts by weight of silica gel. From the concentrated chloroform filtrate there is isolated 20.4 parts by weight of 2-chloro-2'-methyl-6'-ethyl-N-(4-chloro-3,5-dimethylpyrazol-1-yl-methyl)-acetanilide as an oil which completely crystallizes upon milling with 50 ml of petroleum ether (m.p. 66° C. from petroleum ether).

後処理

  1. filtrationit is filtered
  2. concentrationthe filtrate, concentrated to 23.8 parts by weight
  3. filtrationis filtered with 600 parts by volume of chloroform through 50 parts by weight of silica gel

出典と根拠

ORDレコード
ord-c1f449e4e8f649f4b4bf9c686a4df531
出典データセット
uspto-grants-1986_06
特許番号
US04593104

反応ノート

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