Hydrochloric Acid → Hydrochloric Acid
反応式
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C@H:7]([CH2:9][C:10]([O:12][CH3:13])=[O:11])[OH:8])[CH2:3][CH:4]([CH3:6])[CH3:5].[ClH:24]>CO.[Pd]>[NH2:1][C@H:2]([C@H:7]([CH2:9][C:10]([O:12][CH3:13])=[O:11])[OH:8])[CH2:3][CH:4]([CH3:6])[CH3:5].[ClH:24]参加物
6
実験手順
818 mg of Z-Sta-OMe dissolved in 40 ml of methanol are hydrogenated at room temperature and normal pressure in the presence of 190 mg of palladium-on-carbon catalyst (10% Pd) until saturation. During hydrogenation, the pH value is maintained constantly at 5 by the continuous addition of 0.5N HCl. After hydrogenation the catalyst is filtered off and the filtrate is concentrated by evaporation. H-Sta-OMe×HCl is obtained in the form of a colourless foam; Rf (G)=0.21. This crude product is used directly in stage 13.5.
後処理
- customare hydrogenated at room temperature
- filtrationAfter hydrogenation the catalyst is filtered off
- concentrationthe filtrate is concentrated by evaporation
出典と根拠
- ORDレコード
- ord-f87b1843194a4ef3b0919d06a97d2a60
- 出典データセット
- uspto-grants-1986_06
- 特許番号
- US04595677
反応ノート
読み込み中…