Hydrogen Bromide → N-[4-[4-(ethylheptylamino)butyl]phenyl]methanesulfonamide monohydrobromide

HRID 1982482

反応式

HRID 1982482 の反応式
[CH2:1]([N:3]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[CH2:4][CH2:5][CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([NH:14][S:15]([CH3:18])(=[O:17])=[O:16])=[CH:10][CH:9]=1)[CH3:2].[BrH:26]>C(OCC)C>[BrH:26].[CH2:1]([N:3]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[CH2:4][CH2:5][CH2:6][CH2:7][C:8]1[CH:9]=[CH:10][C:11]([NH:14][S:15]([CH3:18])(=[O:16])=[O:17])=[CH:12][CH:13]=1)[CH3:2]

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 9864094N-(4-(4-(Ethylheptylamino)butyl)phenyl)methanesulfonamide

生成物 1

HCID 70387710N-[4-[4-(ethylheptylamino)butyl]phenyl]methanesulfonamide monohydrobromide収率 37%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

N-[4-[4-(ethylheptylamino)butyl]phenyl]methanesulfonamide (5.56 g, 0.015 mol), prepared according to the general procedure outlined in Example 1, was dissolved in diethyl ether. The solution was cooled with a dry ice/acetone bath and diethyl ether saturated with hydrogen bromide gas was added thereto. The volatiles were evaporated under reduced pressure and 100 ml of ethyl acetate was added to the residue. The solution was triturated and approximately 6 grams of crystals were collected. The solid was recrystalized from isopropyl alcohol to provide 2.5 g of N-[4-[4-(ethylheptylamino)butyl]phenyl]methanesulfonamide monohydrobromide. mp=98°-100° C. Yield 37%

後処理

  1. temperatureThe solution was cooled with a dry ice/acetone bath
  2. customThe volatiles were evaporated under reduced pressure and 100 ml of ethyl acetate
  3. additionwas added to the residue
  4. customThe solution was triturated
  5. customapproximately 6 grams of crystals were collected
  6. customThe solid was recrystalized from isopropyl alcohol

出典と根拠

ORDレコード
ord-70253ae8ff4f441392973bf47651d6ac
出典データセット
uspto-grants-1986_06
特許番号
US04596827

関連ノート

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