N-bromobutanimide → 3-Bromo-8-phenylimidazo[1,2-a]pyridine
反応式
[C:1]1([C:7]2[C:8]3[N:9]([CH:13]=[CH:14][N:15]=3)[CH:10]=[CH:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:16]N1C(=O)CCC1=O>C(Cl)Cl>[Br:16][C:13]1[N:9]2[CH:10]=[CH:11][CH:12]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[C:8]2=[N:15][CH:14]=1参加物
4
実験手順
Combine 2 g (10.3 mmol) of the product from Example 4 with 1.8 g (10.3 mmol) of N-bromosuccinimide in 50 ml of methylene chloride, and stir for 10 minutes at room temperature. Wash the reaction mixture with 50 ml of 10% potassium carbonate. Dry the methylene chloride layer over sodium sulfate, treat with charcoal, filter, and remove the solvent in vacuo. Crystallize the residue from ether to provide the title compound.
後処理
- washWash the reaction mixture with 50 ml of 10% potassium carbonate
- dry with materialDry the methylene chloride layer over sodium sulfate
- additiontreat with charcoal
- filtrationfilter
- customremove the solvent in vacuo
- customCrystallize the residue from ether
出典と根拠
- ORDレコード
- ord-72484a54a434498d87ac3b9620ad69f4
- 出典データセット
- uspto-grants-1986_06
- 特許番号
- US04596872
反応ノート
読み込み中…