4-Isopropylaniline → N-[4-(Propan-2-yl)phenyl]ethanimidic acid

HRID 1982742ノート

反応式

HRID 1982742 の反応式
C(O[C:5](=[O:7])[CH3:6])(=O)C.[CH:8]([C:11]1[CH:17]=[CH:16][C:14]([NH2:15])=[CH:13][CH:12]=1)([CH3:10])[CH3:9]>C(Cl)(Cl)Cl>[C:5]([NH:15][C:14]1[CH:16]=[CH:17][C:11]([CH:8]([CH3:10])[CH3:9])=[CH:12][CH:13]=1)(=[O:7])[CH3:6]

参加物

4

反応物 2

HCID 74644-IsopropylanilineHCID 7918Acetic Anhydride

生成物 1

HCID 258025N-[4-(Propan-2-yl)phenyl]ethanimidic acid

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Acetic anhydride (26.0 g, 254 mmol) is slowly added dropwise to a solution of 4-isopropylaniline (17.2 g, 127 mmol) in 80 ml of chloroform. In the course of this, intense heating of the reaction mixture occurs. On completion of the dropwise addition, the mixture is stirred at room temperature for another 2 h. The reaction mixture is concentrated to dryness and the resulting, reddish-white solid is recrystallized from hexane.

後処理

  1. temperatureIn the course of this, intense heating of the reaction mixture
  2. additionOn completion of the dropwise addition
  3. concentrationThe reaction mixture is concentrated to dryness
  4. customthe resulting, reddish-white solid is recrystallized from hexane

出典と根拠

ORDレコード
ord-5971b1fea1034cda9ef8a0c487591110
出典データセット
uspto-grants-2009_06
特許番号
US07540978B2

反応ノート

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