Formaldehyde → [3-(propan-2-yl)-1H-pyrazol-1-yl]methanol

HRID 1982993ノート

反応式

HRID 1982993 の反応式
[CH:1]([C:4]1[CH:8]=[CH:7][NH:6][N:5]=1)([CH3:3])[CH3:2].[CH2:9]=[O:10].C(N(CC)CC)C>CC(C)=O>[CH:1]([C:4]1[CH:8]=[CH:7][N:6]([CH2:9][OH:10])[N:5]=1)([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 712FormaldehydeHCID 8471TriethylamineHCID 178439403HCID 178439403、化合物

生成物 1

HCID 23149190[3-(propan-2-yl)-1H-pyrazol-1-yl]methanol収率 87.5%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
130 °C

実験手順

The mixture of 1.15 g of 3-i-propyl-1H-pyrazole, 0.94 g of paraformaldehyde and 0.14 g of triethylamine was stirred at 130° C. for 7 hours. After the reaction mixture was cooled to room temperature, acetone was added to the reaction mixture. The mixture was filtered. The filterate was concentrated under reduced pressure. Hexane was added to the residue, and then crystalline was formed. The crystalline was collected to obtain 1.28 g of 3-i-propyl-1H-pyrazole-1-ylmethanol.

後処理

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationThe mixture was filtered
  3. concentrationThe filterate was concentrated under reduced pressure
  4. additionHexane was added to the residue
  5. customcrystalline was formed
  6. customThe crystalline was collected

出典と根拠

ORDレコード
ord-eeae46a0051743e3a770b198ff9cba6f
出典データセット
uspto-grants-2009_06
特許番号
US07541374B2

反応ノート

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