Thionyl Chloride → 3-i-propyl-1-(chloromethyl)-1H-pyrazole hydrochloride

HRID 1982994ノート

反応式

HRID 1982994 の反応式
[CH:1]([C:4]1[CH:8]=[CH:7][N:6]([CH2:9]O)[N:5]=1)([CH3:3])[CH3:2].S(Cl)([Cl:13])=O>ClCCl>[ClH:13].[CH:1]([C:4]1[CH:8]=[CH:7][N:6]([CH2:9][Cl:13])[N:5]=1)([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 23149190[3-(propan-2-yl)-1H-pyrazol-1-yl]methanol

生成物 1

HCID 231491783-i-propyl-1-(chloromethyl)-1H-pyrazole hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1.28 g of 3-i-propyl-1H-pyrazole-1-ylmethanol was dissolved to 20 ml of dichloromethane. 2 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 1.58 g of 3-i-propyl-1-(chloromethyl)-1H-pyrazole hydrochloride.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-c6f5aa9115c248108b26d7c6ed139dad
出典データセット
uspto-grants-2009_06
特許番号
US07541374B2

反応ノート

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