Formaldehyde → [3-(trifluoromethyl)-1H-pyrazol-1-yl]methanol

HRID 1982999ノート

反応式

HRID 1982999 の反応式
[F:1][C:2]([F:9])([F:8])[C:3]1[CH:7]=[CH:6][NH:5][N:4]=1.[CH2:10]=[O:11].C(N(CC)CC)C>CC(C)=O>[F:1][C:2]([F:9])([F:8])[C:3]1[CH:7]=[CH:6][N:5]([CH2:10][OH:11])[N:4]=1

参加物

5

反応物 3

HCID 712FormaldehydeHCID 8471TriethylamineHCID 18070343-(Trifluoromethyl)pyrazole

生成物 1

HCID 23149202[3-(trifluoromethyl)-1H-pyrazol-1-yl]methanol収率 86.5%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
80 °C

実験手順

The mixture of 4.08 g of 3-(trifluoromethyl)-1H-pyrazole, 2.00 g of paraformaldehyde and 1 ml of triethylamine was stirred at 80° C. for 5 hours. After the reaction mixture was cooled to room temperature, acetone was added to the reaction mixture. The mixture was filtered. The filterate was concentrated under reduced pressure. Hexane was added to the residue, and then crystalline was formed. The crystalline was collected to obtain 4.31 g of 3-(trifluoromethyl)-1H-pyrazole-1-ylmethanol.

後処理

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationThe mixture was filtered
  3. concentrationThe filterate was concentrated under reduced pressure
  4. additionHexane was added to the residue
  5. customcrystalline was formed
  6. customThe crystalline was collected

出典と根拠

ORDレコード
ord-1dc556a7a7964805b58ede2195bf92a1
出典データセット
uspto-grants-2009_06
特許番号
US07541374B2

反応ノート

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