Thionyl Chloride → 1-(chloromethyl)-3-(trifluoromethyl)-1H-pyrazole

HRID 1983000ノート

反応式

HRID 1983000 の反応式
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:7]=[CH:6][N:5]([CH2:8]O)[N:4]=1.S(Cl)([Cl:14])=O>ClCCl>[Cl:14][CH2:8][N:5]1[CH:6]=[CH:7][C:3]([C:2]([F:11])([F:10])[F:1])=[N:4]1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 23149202[3-(trifluoromethyl)-1H-pyrazol-1-yl]methanol

生成物 1

HCID 196193331-(chloromethyl)-3-(trifluoromethyl)-1H-pyrazole

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1.33 g of 3-(trifluoromethyl)-1H-pyrazole-1-ylmethanol was dissolved to 40 ml of dichloromethane. 2.7 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 1.44 g of 1-(chloromethyl)-3-(trifluoromethyl)-1H-pyrazole.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-945e5508e1e64fcd81ee8f6e1d218a32
出典データセット
uspto-grants-2009_06
特許番号
US07541374B2

反応ノート

読み込み中…