Formaldehyde → 1-(Hydroxymethyl)-1H-pyrazole-3-carbonitrile

HRID 1983003ノート

反応式

HRID 1983003 の反応式
[C:1]([C:3]1[CH:7]=[CH:6][NH:5][N:4]=1)#[N:2].[CH2:8]=[O:9]>CC(C)=O>[OH:9][CH2:8][N:5]1[CH:6]=[CH:7][C:3]([C:1]#[N:2])=[N:4]1

参加物

4

反応物 2

HCID 712FormaldehydeHCID 178510229HCID 178510229、化合物

生成物 1

HCID 231492041-(Hydroxymethyl)-1H-pyrazole-3-carbonitrile収率 78.2%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
130 °C

実験手順

The mixture of 0.86 g of 3-cyano-1H-pyrazole and 0.55 g of paraformaldehyde was stirred at 130° C. for 7 hours. After the reaction mixture was cooled to room temperature, acetone was added to the reaction mixture. After the mixture was filtered, the filterate was concentrated under reduced pressure to obtain 0.89 g of 1-(hydroxymethyl)-3-cyano-1H-pyrazole.

後処理

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationAfter the mixture was filtered
  3. concentrationthe filterate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-b89ab9f59ab34374bd4b9245c26fa816
出典データセット
uspto-grants-2009_06
特許番号
US07541374B2

反応ノート

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