Thionyl Chloride → 1-(chloromethyl)-3-cyano-1H-pyrazole

HRID 1983004ノート

反応式

HRID 1983004 の反応式
O[CH2:2][N:3]1[CH:7]=[CH:6][C:5]([C:8]#[N:9])=[N:4]1.S(Cl)([Cl:12])=O>ClCCl>[C:8]([C:5]1[CH:6]=[CH:7][N:3]([CH2:2][Cl:12])[N:4]=1)#[N:9]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 231492041-(Hydroxymethyl)-1H-pyrazole-3-carbonitrile

生成物 1

HCID 231491551-(chloromethyl)-3-cyano-1H-pyrazole

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

0.89 g of 1-(hydroxymethyl)-3-cyano-1H-pyrazole was dissolved to 30 ml of dichloromethane. 1.6 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 1.00 g of 3-cyano-1-(chloromethyl)-1H-pyrazole.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-4048f98994ec4a3f9dab9965e6aea239
出典データセット
uspto-grants-2009_06
特許番号
US07541374B2

反応ノート

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