Thionyl Chloride → 1-(chloromethyl)-3-phenyl-1H-pyrazole hydrochloride

HRID 1983006ノート

反応式

HRID 1983006 の反応式
[C:1]1([C:7]2[CH:11]=[CH:10][N:9]([CH2:12]O)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:16])=O>ClCCl>[ClH:16].[Cl:16][CH2:12][N:9]1[CH:10]=[CH:11][C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[N:8]1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 23149203(3-phenyl-1H-pyrazol-1-yl)methanol

生成物 1

HCID 231491981-(chloromethyl)-3-phenyl-1H-pyrazole hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1.74 g of 3-phenyl-1H-pyrazole-1-ylmethanol was dissolved to 50 ml of dichloromethane. 3.4 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure. Hexane and chloroform was added to the residue to produce a crystal. The crystal was collected to obtain 2.01 g of 1-(chloromethyl)-3-phenyl-1H-pyrazole hydrochloride.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. additionHexane and chloroform was added to the residue
  3. customto produce a crystal
  4. customThe crystal was collected

出典と根拠

ORDレコード
ord-9e26bc2e22b947a69d9be7f84f70836b
出典データセット
uspto-grants-2009_06
特許番号
US07541374B2

反応ノート

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