Sodium Hydroxide → HCID 178441971、化合物
反応式
[C:1]([C:5]1[CH:9]=[CH:8][NH:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].[Br:12]Br>O>[Br:12][C:9]1[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])=[N:6][NH:7][CH:8]=1参加物
5
反応条件
- 温度
- 0 °C
実験手順
2.48 g of 3-t-butyl-1H-pyrazole was suspended in 35 ml of water, and 2.5 g of 50% aqueous solution of sodium hydroxide was added to it. The mixture was cooled to 0° C., and then 3.50 g of bromine was added to the mixture, followed by stirring at room temperature for 7 hours. The reaction mixture was extracted by ethyl acetate. The organic layer was washed with water dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 3.14 of 4-bromo-3-t-butyl-1H-pyrazole.
後処理
- extractionThe reaction mixture was extracted by ethyl acetate
- washThe organic layer was washed with water
- dry with materialdried over anhydrous magnesium sulfate
- filtrationfiltered
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-6a99de2fe70a43438749455f0e89b660
- 出典データセット
- uspto-grants-2009_06
- 特許番号
- US07541374B2
反応ノート
読み込み中…