Formaldehyde → 4-bromo-3-t-butyl-1H-pyrazole-1-ylmethanol
反応式
[Br:1][C:2]1[C:3]([C:7]([CH3:10])([CH3:9])[CH3:8])=[N:4][NH:5][CH:6]=1.[CH2:11]=[O:12]>C(N(CC)CC)C.CC(C)=O>[Br:1][C:2]1[C:3]([C:7]([CH3:10])([CH3:9])[CH3:8])=[N:4][N:5]([CH2:11][OH:12])[CH:6]=1参加物
5
反応条件
- 温度
- 130 °C
実験手順
The mixture of 3.14 g of 4-bromo-3-t-butyl-1H-pyrazole, 0.93 g of paraformaldehyde and 0.11 g of triethylamine was stirred at 130° C. for 7 hours. After the reaction mixture was cooled to room temperature, acetone was added to the reaction mixture. The mixture was filtered. Hexane was added to the residue obtained by concentration of the filtrate under reduced pressure, as a result, a crystal was formed. The crystal was collected to obtain 3.79 g of 4-bromo-3-t-butyl-1H-pyrazole-1-ylmethanol.
後処理
- temperatureAfter the reaction mixture was cooled to room temperature
- filtrationThe mixture was filtered
- additionHexane was added to the residue
- customobtained by concentration of the filtrate under reduced pressure, as a result
- customa crystal was formed
- customThe crystal was collected
出典と根拠
- ORDレコード
- ord-db0ca102a1c24264b3da0eab9fcbad8a
- 出典データセット
- uspto-grants-2009_06
- 特許番号
- US07541374B2
反応ノート
読み込み中…