Thionyl Chloride → 4-bromo-3-t-butyl-1-(chloromethyl)-1H-pyrazole hydrochloride

HRID 1983012ノート

反応式

HRID 1983012 の反応式
[Br:1][C:2]1[C:3]([C:9]([CH3:12])([CH3:11])[CH3:10])=[N:4][N:5]([CH2:7]O)[CH:6]=1.S(Cl)([Cl:15])=O>ClCCl>[ClH:15].[Br:1][C:2]1[C:3]([C:9]([CH3:12])([CH3:11])[CH3:10])=[N:4][N:5]([CH2:7][Cl:15])[CH:6]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 231491454-bromo-3-t-butyl-1H-pyrazole-1-ylmethanol

生成物 1

HCID 231491914-bromo-3-t-butyl-1-(chloromethyl)-1H-pyrazole hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

3.79g of 4-bromo-3-t-butyl-1H-pyrazole-1-ylmethanol was dissolved to 45 ml of dichloromethane. 3.4 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure. The solid obtained was washed with hexane and chloroform to obtain 3.69 g of 4-bromo-3-t-butyl-1-(chloromethyl)-1H-pyrazole hydrochloride.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customThe solid obtained
  3. washwas washed with hexane and chloroform

出典と根拠

ORDレコード
ord-56fd97145ef649b2b0011fc8590641ef
出典データセット
uspto-grants-2009_06
特許番号
US07541374B2

反応ノート

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