Formaldehyde → 4-bromo-3-(trifluoromethyl)-1H-pyrazole-1-ylmethanol

HRID 1983017ノート

反応式

HRID 1983017 の反応式
[Br:1][C:2]1[C:3]([C:7]([F:10])([F:9])[F:8])=[N:4][NH:5][CH:6]=1.[CH2:11]=[O:12]>CC(C)=O>[Br:1][C:2]1[C:3]([C:7]([F:10])([F:9])[F:8])=[N:4][N:5]([CH2:11][OH:12])[CH:6]=1

参加物

4

反応物 2

HCID 712FormaldehydeHCID 178506296HCID 178506296、化合物

生成物 1

HCID 231491424-bromo-3-(trifluoromethyl)-1H-pyrazole-1-ylmethanol収率 85.1%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
140 °C

実験手順

The mixture of 3.38 g of 4-bromo-3-(trifluoromethyl)-1H-pyrazole and 0.66 g of paraformaldehyde was stirred at 140° C. for 5 hours. After the reaction mixture was cooled to room temperature, acetone was added to the reaction mixture. The mixture was filtered. Hexane was added to the residue obtained by concentration of the filtrate under reduced pressure, as a result, a crystal was formed. The crystal was collected to obtain 3.28 g of 4-bromo-3-(trifluoromethyl)-1H-pyrazole-1-ylmethanol.

後処理

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationThe mixture was filtered
  3. additionHexane was added to the residue
  4. customobtained by concentration of the filtrate under reduced pressure, as a result
  5. customa crystal was formed
  6. customThe crystal was collected

出典と根拠

ORDレコード
ord-f662bb82c3de4544a643ac2e08139b7e
出典データセット
uspto-grants-2009_06
特許番号
US07541374B2

反応ノート

読み込み中…