Thionyl Chloride → 4-bromo-1-(chloromethyl)-3-(trifluoromethyl)-1H-pyrazole

HRID 1983018ノート

反応式

HRID 1983018 の反応式
[Br:1][C:2]1[C:3]([C:9]([F:12])([F:11])[F:10])=[N:4][N:5]([CH2:7]O)[CH:6]=1.S(Cl)([Cl:15])=O>ClCCl>[Br:1][C:2]1[C:3]([C:9]([F:12])([F:11])[F:10])=[N:4][N:5]([CH2:7][Cl:15])[CH:6]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 231491424-bromo-3-(trifluoromethyl)-1H-pyrazole-1-ylmethanol

生成物 1

HCID 231491474-bromo-1-(chloromethyl)-3-(trifluoromethyl)-1H-pyrazole

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

3.28 g of 4-bromo-3-(trifluoromethyl)-1H-pyrazole-1-ylmethanol was dissolved to 40 ml of dichloromethane. 2.9 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure. The obtained solid was washed with the mixture of hexane and chloroform to obtain 3.33 g of 4-bromo-1-(chloromethyl)-3-(trifluoromethyl)-1H-pyrazole.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. washThe obtained solid was washed with the mixture of hexane and chloroform

出典と根拠

ORDレコード
ord-744ce6921e4a47f9907faf0034c55224
出典データセット
uspto-grants-2009_06
特許番号
US07541374B2

反応ノート

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