Thionyl Chloride → 4-chloro-1-(chloromethyl)-1H-pyrazole hydrochloride

HRID 1983021ノート

反応式

HRID 1983021 の反応式
[Cl:1][C:2]1[CH:3]=[N:4][N:5]([CH2:7]O)[CH:6]=1.S(Cl)([Cl:11])=O>ClCCl>[ClH:1].[Cl:1][C:2]1[CH:3]=[N:4][N:5]([CH2:7][Cl:11])[CH:6]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 7017837(4-chloro-1H-pyrazol-1-yl)methanol

生成物 1

HCID 231491194-chloro-1-(chloromethyl)-1H-pyrazole hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2.73 g of 4-chloro-1H-pyrazole-1-ylmethanol was dissolved to 20 ml of dichloromethane. 4.4 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 2.90 g of 4-chloro-1-(chloromethyl)-1H-pyrazole hydrochloride.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-4ba79de6830f453fbdf6b7841f6f2834
出典データセット
uspto-grants-2009_06
特許番号
US07541374B2

反応ノート

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