Formaldehyde → 4-(Trifluoromethyl)-1H-pyrazole-1-methanol

HRID 1983023ノート

反応式

HRID 1983023 の反応式
[F:1][C:2]([F:9])([F:8])[C:3]1[CH:4]=[N:5][NH:6][CH:7]=1.[CH2:10]=[O:11]>CC(C)=O>[F:1][C:2]([F:9])([F:8])[C:3]1[CH:4]=[N:5][N:6]([CH2:10][OH:11])[CH:7]=1

参加物

4

反応物 2

HCID 712FormaldehydeHCID 127777954-(Trifluoromethyl)-1H-pyrazole

生成物 1

HCID 231491674-(Trifluoromethyl)-1H-pyrazole-1-methanol収率 83.3%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
130 °C

実験手順

The mixture of 0.59 g of 4-(trifluoromethyl)-1H-pyrazole and 0.26 g of paraformaldehyde was stirred at 130° C. for 4 hours. After the reaction mixture was cooled to room temperature, acetone was added to the reaction mixture. The mixture was filtered. The residue was concentration under reduced pressure to obtain 0.60 g of 4-(trifluoromethyl)-1H-pyrazole-1-ylmethanol.

後処理

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationThe mixture was filtered
  3. concentrationconcentration under reduced pressure

出典と根拠

ORDレコード
ord-f77e9e4b74ab44bf8ad91cda84084c59
出典データセット
uspto-grants-2009_06
特許番号
US07541374B2

反応ノート

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