Thionyl Chloride → methyl 1-(chloromethyl)-1H-pyrazole-4-carboxylate

HRID 1983026ノート

反応式

HRID 1983026 の反応式
O[CH2:2][N:3]1[CH:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[N:4]1.S(Cl)([Cl:14])=O>ClCCl>[Cl:14][CH2:2][N:3]1[CH:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[N:4]1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 23149172methyl 1-(hydroxymethyl)-1H-pyrazole-4-carboxylate

生成物 1

HCID 7017727methyl 1-(chloromethyl)-1H-pyrazole-4-carboxylate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1.38 g of 1-(hydroxymethyl)-4-methoxycarbonyl-1H-pyrazole was dissolved to 10 ml of dichloromethane. 1 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 1.59 g of 1-(chloromethyl)-4-methoxycarbonyl-1H-pyrazole.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-65e58aff5c4a475398d6318ae059338a
出典データセット
uspto-grants-2009_06
特許番号
US07541374B2

反応ノート

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