Formaldehyde → 1-(Hydroxymethyl)-3-(trifluoromethyl)-1H-1,2,4-triazole

HRID 1983037ノート

反応式

HRID 1983037 の反応式
[F:1][C:2]([F:9])([F:8])[C:3]1[N:7]=[CH:6][NH:5][N:4]=1.[CH2:10]=[O:11]>CC(C)=O>[F:1][C:2]([F:9])([F:8])[C:3]1[N:7]=[CH:6][N:5]([CH2:10][OH:11])[N:4]=1

参加物

4

反応物 2

HCID 712FormaldehydeHCID 178506277HCID 178506277、化合物

生成物 1

HCID 231491401-(Hydroxymethyl)-3-(trifluoromethyl)-1H-1,2,4-triazole収率 94.3%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
150 °C

実験手順

The mixture of 2.74 g of 3-(trifluoromethyl)-1H-1,2,4-triazole and 1.20 g of paraformaldehyde was stirred at 150° C. for 5 hours. After the reaction mixture was cooled to room temperature, acetone was added to the reaction mixture, and the mixture was filtered. The filtrate was concentrated. The residue was subjected to silica gel column chromatography to obtain 3.15 g of 3-(trifluoromethyl)-1H-1,2,4-triazole 1-ylmethanol.

後処理

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationthe mixture was filtered
  3. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-62a792cdb76445bc966e229dbf830580
出典データセット
uspto-grants-2009_06
特許番号
US07541374B2

反応ノート

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