Thionyl Chloride → 1-(chloromethyl)-3-(trifluoromethyl)-1H-1,2,4-triazole

HRID 1983038ノート

反応式

HRID 1983038 の反応式
[F:1][C:2]([F:11])([F:10])[C:3]1[N:7]=[CH:6][N:5]([CH2:8]O)[N:4]=1.S(Cl)([Cl:14])=O>ClCCl>[Cl:14][CH2:8][N:5]1[CH:6]=[N:7][C:3]([C:2]([F:11])([F:10])[F:1])=[N:4]1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 231491401-(Hydroxymethyl)-3-(trifluoromethyl)-1H-1,2,4-triazole

生成物 1

HCID 231491371-(chloromethyl)-3-(trifluoromethyl)-1H-1,2,4-triazole

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1.52 g of 3-(trifluoromethyl)-1H-1,2,4-triazole 1-ylmethanol was dissolved to 50 ml of dichloromethane, and 2.7 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 1.36 g of 1-(chloromethyl)-3-(trifluoromethyl)-1H-1,2,4-triazole.

後処理

  1. additionwas added to the solution
  2. concentrationThe reaction mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-78c4601423424f22baf8de452c249ad8
出典データセット
uspto-grants-2009_06
特許番号
US07541374B2

反応ノート

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