Formaldehyde → 3-(pentafluoroethyl)-1H-1,2,4-triazole 1-ylmethanol
反応式
[F:1][C:2]([F:12])([C:7]1[N:11]=[CH:10][NH:9][N:8]=1)[C:3]([F:6])([F:5])[F:4].[CH2:13]=[O:14]>CC(C)=O>[F:12][C:2]([F:1])([C:7]1[N:11]=[CH:10][N:9]([CH2:13][OH:14])[N:8]=1)[C:3]([F:6])([F:5])[F:4]参加物
4
反応条件
- 温度
- 150 °C
実験手順
The mixture of 1.45 g of 3-(pentafluoroethyl)-1H-1,2,4-triazole and 0.46 g of paraformaldehyde was stirred at 150° C. for 5 hours. After the reaction mixture was cooled to room temperature, acetone was added. The mixture was filtered. The filtrate was concentrated. Hexane was added to the residue, as a result, a crystal was formed. The crystal was collected to obtain 1.52 g of 3-(pentafluoroethyl)-1H-1,2,4-triazole 1-ylmethanol.
後処理
- temperatureAfter the reaction mixture was cooled to room temperature
- filtrationThe mixture was filtered
- concentrationThe filtrate was concentrated
- additionHexane was added to the residue, as a result
- customa crystal was formed
- customThe crystal was collected
出典と根拠
- ORDレコード
- ord-afc0b764cab24b808968e20c9a4eb568
- 出典データセット
- uspto-grants-2009_06
- 特許番号
- US07541374B2
反応ノート
読み込み中…