Sodium Hydroxide → HCID 178506331、化合物

HRID 1983044ノート

反応式

HRID 1983044 の反応式
[F:1][C:2]([F:12])([C:7]1[CH:11]=[CH:10][NH:9][N:8]=1)[C:3]([F:6])([F:5])[F:4].[OH-].[Na+].[Br:15]Br>O>[Br:15][C:11]1[C:7]([C:2]([F:1])([F:12])[C:3]([F:6])([F:5])[F:4])=[N:8][NH:9][CH:10]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 24408BromineHCID 1785063263-(pentafluoroethyl)-1H-pyrazole

生成物 1

HCID 178506331HCID 178506331、化合物収率 103.6%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
0 °C

実験手順

9.30 g of 3-(pentafluoroethyl)-1H-pyrazole was suspended to 90 ml of water, and 6.0 g of 50% aqueous solution of sodium hydroxide was added to the suspension. The mixture was cooled to 0° C., then 8.79 g of bromine was added to the mixture, followed by stirring at room temperature for 7 hours. The reaction mixture was extracted by ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium salfate, filtered, and concentrated under reduced pressure to obtain 13.72 g of 4-bromo-3-(pentafluoroethyl)-1H-pyrazole.

後処理

  1. additionwas added to the suspension
  2. extractionThe reaction mixture was extracted by ethyl acetate
  3. washThe organic layer was washed with water
  4. dry with materialdried over anhydrous magnesium salfate
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-c6db249ae75c4745986a803d2a414c46
出典データセット
uspto-grants-2009_06
特許番号
US07541374B2

反応ノート

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