Formaldehyde → 4-bromo-3-(pentafluoroethyl)-1H-pyrazole-1-ylmethanol

HRID 1983045ノート

反応式

HRID 1983045 の反応式
[Br:1][C:2]1[C:3]([C:7]([F:13])([F:12])[C:8]([F:11])([F:10])[F:9])=[N:4][NH:5][CH:6]=1.[CH2:14]=[O:15]>CC(C)=O>[Br:1][C:2]1[C:3]([C:7]([F:13])([F:12])[C:8]([F:9])([F:10])[F:11])=[N:4][N:5]([CH2:14][OH:15])[CH:6]=1

参加物

4

反応物 2

HCID 712FormaldehydeHCID 178506331HCID 178506331、化合物

生成物 1

HCID 231491334-bromo-3-(pentafluoroethyl)-1H-pyrazole-1-ylmethanol収率 50.3%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
130 °C

実験手順

The mixture of 13.72 g of 4-bromo-3-(pentafluoroethyl)-1H-pyrazole and 3.00 g of paraformaldehyde was stirred at 130° C. for 5 hours. After the reaction mixture was cooled to room temperature, acetone was added. The mixture was filtered. The filtrate was concentrated under reduced pressure. Hexane was added to the filtrate, as a result, a crystal was formed. The crystal was collected to obtain 7.69 g of 4-bromo-3-(pentafluoroethyl)-1H-pyrazole-1-ylmethanol.

後処理

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationThe mixture was filtered
  3. concentrationThe filtrate was concentrated under reduced pressure
  4. additionHexane was added to the filtrate, as a result
  5. customa crystal was formed
  6. customThe crystal was collected

出典と根拠

ORDレコード
ord-c67c9c6a8c9245d48876786e720d34a7
出典データセット
uspto-grants-2009_06
特許番号
US07541374B2

反応ノート

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