Water → 1-Bromo-4-fluoro-2-propoxybenzene
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[OH:9].C(=O)([O-])[O-].[K+].[K+].I[CH2:17][CH2:18][CH3:19].O>CN(C)C=O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[O:9][CH2:17][CH2:18][CH3:19]参加物
6
実験手順
A total of 5 g of 2-bromo-5-fluoro-phenol was dissolved in 66 ml of N,N-dimethylformamide. Under ice-cooling, 5.42 g of potassium carbonate and 3.07 ml of iodopropane were added, and the mixture was stirred at room temperature for 10 hours. Water was added to the reaction mixture, followed by extracting with diethyl ether. The resulting organic layer was washed with brine, dried over magnesium sulfate and the solvent was evaporated, to give 8.29 g of the title compound as a yellow oil.
後処理
- temperatureUnder ice-cooling
- extractionby extracting with diethyl ether
- washThe resulting organic layer was washed with brine
- dry with materialdried over magnesium sulfate
- customthe solvent was evaporated
出典と根拠
- ORDレコード
- ord-a0334d8e2adf4021ac9be0214f069445
- 出典データセット
- uspto-grants-2009_06
- 特許番号
- US07541376B2
反応ノート
読み込み中…