HCID 57713314、化合物 → HCID 68867444、化合物
反応式
[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[C:5]([N+:12]([O-])=O)=[CH:4][C:3]=1[OH:15].[H][H]>C1COCC1.[Ni]>[NH2:12][C:5]1[C:6]([C:8]([F:11])([F:9])[F:10])=[CH:7][C:2]([F:1])=[C:3]([OH:15])[CH:4]=1参加物
5
実験手順
Raney-Ni (0.5 g) was added to a solution of 2-fluoro-5-nitro-4-(trifluoromethyl)phenol obtained in Reference Example 17 (0.5 g) in THF (5 ml), and the mixture was stirred for 2 hours in a hydrogen atmosphere. The catalyst was removed by filtration and the catalyst was washed with THF. The combined filtrate and washings were diluted with THF to obtain a solution of 5-amino-2-fluoro-4-(trifluoromethyl)phenol in THF (50 ml).
後処理
- customThe catalyst was removed by filtration
- washthe catalyst was washed with THF
- additionThe combined filtrate and washings were diluted with THF
出典と根拠
- ORDレコード
- ord-0ce59d1b3d9b4b549d9c144b1a7f0b2a
- 出典データセット
- uspto-grants-2009_06
- 特許番号
- US07541478B2
反応ノート
読み込み中…