Dimethyl Sulfoxide → Benzenemethanol, alpha-ethenyl-, 1-acetate

温度

40 °C

In a one liter 3-neck round bottom flask equipped with a condenser, mechanical stirrer and thermometer, 108 grams (0.708 mol) of vinylbenzyl chloride (60/40 m-/p-) and 808 grams (0.815 mol) of potassium acetate were added, followed by 250 mLs of DMSO. The mixture was stirred at 40° C. for 48 hours. After allowing to cool to room temperature, the mixture was diluted with water and poured into a separatory funnel. The organic layer was separated, followed by an extraction of the aqueous layer with chloroform. The combined organic layer was then washed with water, dried over magnesium sulfate and placed on the rotary evaporator to remove the chloroform. 120 grams of the vinylbenzyl acetate product was recovered, to which 10 mg of MEHQ was added as an inhibitor.

1. customIn a one liter 3-neck round bottom flask equipped with a condenser, mechanical stirrer
2. temperatureto cool to room temperature
3. additionpoured into a separatory funnel
4. customThe organic layer was separated
5. extractionfollowed by an extraction of the aqueous layer with chloroform
6. washThe combined organic layer was then washed with water
7. dry with materialdried over magnesium sulfate
8. customplaced on the rotary evaporator
9. customto remove the chloroform
10. custom120 grams of the vinylbenzyl acetate product was recovered, to which 10 mg of MEHQ
11. additionwas added as an inhibitor

ORDレコード

ord-af0c0b19934242bfaa47c6791779d4f5

出典データセット

uspto-grants-2009_06

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07544453B2