(5-Fluoromethylpyridin-2-yl)methanol → 5-(Fluoromethyl)picolinaldehyde
反応式
[F:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][OH:10])=[N:7][CH:8]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[F:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]=[O:10])=[N:7][CH:8]=1参加物
4
実験手順
Manganese dioxide (1.4 g) is added in a single portion to a solution of compound (5) (0.3 g) in chloroform (5 ml) at room temperature. The suspension is stirred vigorously for 7 hours and then diluted with chloroform and filtered through Celite. The filtrate is concentrated under vacuum and the yellow oil obtained (0.25 g) is used in its present form in the following reductive amination step.
後処理
- filtrationfiltered through Celite
- concentrationThe filtrate is concentrated under vacuum
- customthe yellow oil obtained (0.25 g)
出典と根拠
- ORDレコード
- ord-b9294ab3250e4e2887e69d869f8f68e4
- 出典データセット
- uspto-grants-2009_06
- 特許番号
- US07547700B2
反応ノート
読み込み中…