化工社化工社 化学情報印刷レポート · 研究参考用
1-(3-Aminopropyl)-4-methylpiperazine → [5-Bromo-4-(7-methoxybenzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(3-Aminopropyl)-4-methylpiperazine | HCID 78328 | — |
| 反応物 | [4-(Benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride | HCID 68855962 | — |
| 反応物 | 5-Bromo-2-chloro-4-(7-methoxy-benzo[b]thiophen-2-yl)-pyrimidine | HCID 86625370 | — |
| 生成物 | [5-Bromo-4-(7-methoxybenzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride | HCID 68856938 | — |
反応手順
Using the method of [4-(benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride, the title compound is prepared from 5-bromo-2-chloro-4-(7-methoxy-benzo[b]thiophen-2-yl)-pyrimidine and 1-(3-aminopropyl)-4-methylpiperazine and isolated as a yellow solid. ES+(m/z) 476 (79Br) and 478 (81Cl) [M+H].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07547691B2 |
| 出典データセット | uspto-grants-2009_06 |
| ORD ID | ord-93cbef253ef146b4938fec8ce1447d5e |
| 出典メモ | uspto-grants-2009_06 |