tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate → HCID 68857404、化合物

HRID 1986255

反応式

HRID 1986255 の反応式
[ClH:1].Cl.Cl.S1C(C2C=CN=C(NCCCN3CCN(C)CC3)N=2)=CC2C=CC=CC1=2.[CH:30]1([NH:33][C:34]([C:36]2[C:44]3[CH:43]=[C:42]([C:45]4[C:50]([Cl:51])=[CH:49][N:48]=[C:47](Cl)[N:46]=4)[S:41][C:40]=3[CH:39]=[CH:38][CH:37]=2)=[O:35])[CH2:32][CH2:31]1.C(OC([N:60]1[CH2:65][CH2:64][N:63]([CH2:66][CH2:67][NH2:68])[CH2:62][CH2:61]1)=O)(C)(C)C>>[ClH:51].[ClH:1].[ClH:51].[CH:30]1([NH:33][C:34]([C:36]2[C:44]3[CH:43]=[C:42]([C:45]4[C:50]([Cl:51])=[CH:49][N:48]=[C:47]([NH:68][CH2:67][CH2:66][N:63]5[CH2:64][CH2:65][NH:60][CH2:61][CH2:62]5)[N:46]=4)[S:41][C:40]=3[CH:39]=[CH:38][CH:37]=2)=[O:35])[CH2:32][CH2:31]1

参加物

4

反応物 3

HCID 1514400tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylateHCID 68855962[4-(Benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochlorideHCID 866253512-(2,5-Dichloropyrimidin-4-yl)-benzo[b]thiophene-4-carboxylic acid cyclopropylamide

生成物 1

HCID 68857404HCID 68857404、化合物

実験手順

Using the method of [4-(benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride, the title compound is synthesized from 2-(2,5-dichloro-pyrimidin-4-yl)-benzo[b]thiophene-4-carboxylic acid cyclopropylamide and 4-(2-amino-ethyl)-piperazine-1-carboxylic acid tert-butyl ester and isolated as a yellow solid (80% yield). ES+(m/z) 457 (35Cl) and 459 (37Cl) [M(free base)+H].

出典と根拠

ORDレコード
ord-54a0a2b717e248feb44bd2c85c249ed5
出典データセット
uspto-grants-2009_06
特許番号
US07547691B2

関連ノート

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