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tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate → 2-[5-Chloro-2-(2-piperazin-1-ylethylamino)-pyrimidin-4-yl]-benzo[b]thiophene-4-carboxylic acid cyclopropylamide tri-hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate | HCID 1514400 | — |
| 反応物 | [4-(Benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride | HCID 68855962 | — |
| 反応物 | 2-(2,5-Dichloropyrimidin-4-yl)-benzo[b]thiophene-4-carboxylic acid cyclopropylamide | HCID 86625351 | — |
| 生成物 | 2-[5-Chloro-2-(2-piperazin-1-ylethylamino)-pyrimidin-4-yl]-benzo[b]thiophene-4-carboxylic acid cyclopropylamide tri-hydrochloride | HCID 68857404 | — |
反応手順
Using the method of [4-(benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride, the title compound is synthesized from 2-(2,5-dichloro-pyrimidin-4-yl)-benzo[b]thiophene-4-carboxylic acid cyclopropylamide and 4-(2-amino-ethyl)-piperazine-1-carboxylic acid tert-butyl ester and isolated as a yellow solid (80% yield). ES+(m/z) 457 (35Cl) and 459 (37Cl) [M(free base)+H].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07547691B2 |
| 出典データセット | uspto-grants-2009_06 |
| ORD ID | ord-54a0a2b717e248feb44bd2c85c249ed5 |
| 出典メモ | uspto-grants-2009_06 |