(2,5-Dichloropyridin-3-yl)(2-fluoro-3-methoxy-6-vinylphenyl)methanol → (2,5-Dichloropyridin-3-yl)(2-fluoro-3-methoxy-6-vinylphenyl)methanone

HRID 1987143ノート

反応式

HRID 1987143 の反応式
[Cl:1][C:2]1[C:7]([CH:8]([C:10]2[C:15]([CH:16]=[CH2:17])=[CH:14][CH:13]=[C:12]([O:18][CH3:19])[C:11]=2[F:20])[OH:9])=[CH:6][C:5]([Cl:21])=[CH:4][N:3]=1>C(Cl)Cl.O=[Mn]=O>[Cl:1][C:2]1[C:7]([C:8]([C:10]2[C:15]([CH:16]=[CH2:17])=[CH:14][CH:13]=[C:12]([O:18][CH3:19])[C:11]=2[F:20])=[O:9])=[CH:6][C:5]([Cl:21])=[CH:4][N:3]=1

参加物

4

反応物 1

HCID 86609785(2,5-Dichloropyridin-3-yl)(2-fluoro-3-methoxy-6-vinylphenyl)methanol

生成物 1

HCID 86609786(2,5-Dichloropyridin-3-yl)(2-fluoro-3-methoxy-6-vinylphenyl)methanone

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of (2,5-dichloropyridin-3-yl)(2-fluoro-3-methoxy-6-vinylphenyl)methanol (11.6 g, 35.3 mmol) in CH2Cl2 (400 mL) was added MnO2 (80 g, 920 mmol). The reaction mixture was allowed to stir overnight, filtered through a pad of Celite, and concentrated to afford the title compound. LRMS (ESI) calc'd for (C15H10Cl2FNO2) [M+H]+, 326.0; found 326.0.

後処理

  1. filtrationfiltered through a pad of Celite
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-f6851668dee44ee8967c81e0a7092898
出典データセット
uspto-grants-2009_06
特許番号
US07550478B2

反応ノート

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