Thionyl Chloride → HCID 86616005、化合物

HRID 1987579ノート

反応式

HRID 1987579 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](O)(=[O:10])=[O:9])=[CH:4][C:3]=1[S:12][CH3:13].S(Cl)([Cl:16])=O>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([Cl:16])(=[O:10])=[O:9])=[CH:4][C:3]=1[S:12][CH3:13]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 86616004HCID 86616004、化合物

生成物 1

HCID 86616005HCID 86616005、化合物収率 8%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
85 °C

実験手順

To a mixture of 4-chloro-3-methylsulfanyl-benzenesulfonic acid (24 mmol) in anhydrous toluene (100 mL) at 0° C. was added thionyl chloride (2.62 mL, 36 mmol). The ice bath was removed and the reaction heated to 85° C. for 5 h, then 70° C. for 18 h. Unreacted starting material was still present by LC-MS and thionyl chloride (5 mL) was added and the reaction stirred for 18 hours at 70° C. The solvent was removed to give a black oil (470 mg, 8%) that was used as is in the next reaction.

後処理

  1. customThe ice bath was removed
  2. additionwas added
  3. customThe solvent was removed

出典と根拠

ORDレコード
ord-0905ec078e524623b5e5158509cf6212
出典データセット
uspto-grants-2009_06
特許番号
US07550629B2

反応ノート

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